Medical Physics

A new fabrication technique to form complex polymethylmethacrylate microchannel for bioseparation

Talukder Z. Jubery, Mohammad R. Hossan, Danny R. Bottenus, Cornelius F. Ivory, Wenji Dong et al.
Recent studies show that reduction in cross-sectional area can be used to improve the concentration factor in microscale bioseparations. Due to simplicity in fabrication process, a step reduction in cross-sectional area is generally implemented in microchip to increase the concentration factor. But ... [Biomicrofluidics 6, 016503 (2012)] published Fri Feb 10, 2012.

Kinetic pathways to peptide aggregation on surfaces: The effects of beta-sheet propensity and surface attraction

Alex Morriss-Andrews and Joan-Emma Shea
Mechanisms of peptide aggregation on hydrophobic surfaces are explored using molecular dynamics simulations with a coarse-grained peptide representation. Systems of peptides are studied with varying degrees of backbone rigidity (a measure of beta-sheet propensity) and degrees of attraction between t ... [J. Chem. Phys. 136, 065103 (2012)] published Fri Feb 10, 2012.

Absorption by DNA single strands of adenine isolated in vacuo: The role of multiple chromophores

Lisbeth Munksgaard Nielsen, Sara Ovad Pedersen, Maj-Britt Suhr Kirketerp, and Steen Brondsted Nielsen
The degree of electronic coupling between DNA bases is a topic being up for much debate. Here we report on the intrinsic electronic properties of isolated DNA strands in vacuo free of solvent, which is a good starting point for high-level excited states calculations. Action spectra of DNA single str ... [J. Chem. Phys. 136, 064302 (2012)] published Fri Feb 10, 2012.

Self-Organized Transition to Coherent Activity in Disordered Media

Rajeev Singh, Jinshan Xu, Nicolas G. Garnier, Alain Pumir, and Sitabhra Sinha
Synchronized oscillations are of critical functional importance in many biological systems. We show that such oscillations can arise without centralized coordination in a disordered system of electrically coupled excitable and passive cells. Increasing the coupling strength results in waves that lea ... [Phys. Rev. Lett. 108, 068102 ] published .

Wafer-scale fabrication of high-aspect ratio nanochannels based on edge-lithography technique

Quan Xie, Qing Zhou, Fei Xie, Jianming Sang, Wei Wang et al.
This paper introduced a wafer-scale fabrication approach for the preparation of nanochannels with high-aspect ratio (the ratio of the channel depth to its width). Edge lithography was used to pattern nanogaps in an aluminum film, which was functioned as deep reactive ion etching mask thereafter to f ... [Biomicrofluidics 6, 016502 (2012)] published Thu Feb 9, 2012.

High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment

Patricia Rosa, Sandra Tenreiro, Virginia Chu, Tiago F. Outeiro, and Joao Pedro Conde
Microfluidics is an emerging technology which allows the miniaturization, integration, and automation of fluid handling processes. Microfluidic systems offer low sample consumption, significantly reduced processing time, and the prospect of massive parallelization. A microfluidic platform was develo ... [Biomicrofluidics 6, 014109 (2012)] published Thu Feb 9, 2012.

Dynamics and efficiency of a self-propelled, diffusiophoretic swimmer

Benedikt Sabass and Udo Seifert
Active diffusiophoresisswimming through interaction with a self-generated, neutral, solute gradientis a paradigm for autonomous motion at the micrometer scale. We study this propulsion mechanism within a linear response theory. First, we consider several aspects relating to the dynamics of the swimm ... [J. Chem. Phys. 136, 064508 (2012)] published Thu Feb 9, 2012.

Folding of small origamis

Jean Michel Arbona, Jean-Pierre Aime, and Juan Elezgaray
A model that preserves the known thermodynamic properties of double stranded DNA is introduced to study the formation of more complex DNA constructions, such as small origamis or Holliday junctions. We show that the thermodynamic behaviour of these complex DNA constructions is not only given by thei ... [J. Chem. Phys. 136, 065102 (2012)] published Thu Feb 9, 2012.

Test bench to commission a third ion source beam line and a newly designed extraction system

T. Winkelmann, R. Cee, T. Haberer, B. Naas, and A. Peters
The HIT (Heidelberg Ion Beam Therapy Center) is the first hospital-based treatment facility in Europe where patients can be irradiated with protons and carbon ions. Since the commissioning starting in 2006 two 14.5 GHz electron cyclotron resonance ion sources are routinely used to produce a variety ... [Rev. Sci. Instrum. 83, 02B904 (2012)] published Thu Feb 9, 2012.

Fabrication of Fe@mSiO nanowires with large remanence and low cytotoxicity for targeted drug delivery

Meng-Meng Song, Hong Bi, and Ye Zhang
Core-shell structured Fe@mSiO nanowires for targeted drug delivery have been prepared through electrodeposition followed by a CTAB-template sol-gel process. The magnetic Fe nanowire core has a diameter of ~40 nm and the mesoporous silica shell has a uniform thickness of ~40 nm with an average pore s ... [J. Appl. Phys. 111, 07B302 (2012)] published Thu Feb 9, 2012.

Cellular and molecular responses of Neurospora crassa to non-thermal plasma at atmospheric pressure

Gyungsoon Park, Young H. Ryu, Young J. Hong, Eun H. Choi, and Han S. Uhm
Filamentous fungi have been rarely explored in terms of plasma treatments. This letter presents the cellular and molecular responses of the filamentous fungus Neurospora crassa to an argon plasma jet at atmospheric pressure. The viability and cell morphology of N. crassa spores exposed to plasma wer ... [Appl. Phys. Lett. 100, 063703 (2012)] published Thu Feb 9, 2012.

Publisher's Note: Magnetic Resonance Imaging by Synergistic Diffusion-Diffraction Patterns [Phys. Rev. Lett. 108, 058103 (2012)]

Noam Shemesh, Carl-Fredrik Westin, and Yoram Cohen
Abstract not available. [Phys. Rev. Lett. 108, 069902 ] published .

Minimalistic behavioral rule derived from bacterial chemotaxis in a stochastic resonance setup

Shuhei Ikemoto, Fabio DallaLibera, Koh Hosoda, and Hiroshi Ishiguro
Animals are able to cope with the noise, uncertainties, and complexity of the real world. Often even elementary living beings, equipped with very limited sensory organs, are able to reach regions favorable to their existence, using simple stochastic policies. In this paper we discuss a minimalistic ... [Phys. Rev. E 85, 021905 ] published .

Nonlinear effective-medium theory of disordered spring networks

M. Sheinman, C. P. Broedersz, and F. C. MacKintosh
Disordered soft materials, such as fibrous networks in biological contexts, exhibit a nonlinear elastic response. We study such nonlinear behavior with a minimal model for networks on lattice geometries with simple Hookian elements with disordered spring constant. By developing a mean-field approach ... [Phys. Rev. E 85, 021801 ] published .

Remote lasing in air by recombination and electron impact excitation of molecular nitrogen

Joseph Penano, Phillip Sprangle, Bahman Hafizi, Daniel Gordon, Richard Fernsler et al.
We analyze and simulate the physical mechanisms for a remote atmospheric lasing configuration which utilizes a combination of an ultrashort pulse laser to form a plasma filament of seed electrons, and a heater beam to heat the seed electrons. Nitrogen molecules are excited by electron impact and rec ... [J. Appl. Phys. 111, 033105 (2012)] published Wed Feb 8, 2012.

Acoustically-observable properties of adult gait

Marshall Bradley and James M. Sabatier
An approach has been developed for extracting human gait parameters from micro Doppler sonar grams. Key parameters include average speed of walking, torso velocity, walk cycle time, and peak leg velocity. The approach is a modification of a technique previously used in radar data analysis. It has be ... [J. Acoust. Soc. Am. 131, EL210 (2012)] published Wed Feb 8, 2012.

Aerial ultrasonic micro Doppler sonar detection range in outdoor environments

Marshall Bradley and James M. Sabatier
Current research demonstrates that micro Doppler sonar has the capability to uniquely identify the presence of a moving human, making it an attractive component in surveillance systems for border security applications. Primary environmental factors that limit sonar performance are two-way spreading ... [J. Acoust. Soc. Am. 131, EL203 (2012)] published Wed Feb 8, 2012.

Duty ratio of cooperative molecular motors

Nadiv Dharan and Oded Farago
Molecular motors are found throughout the cells of the human body and have many different and important roles. These micromachines move along filament tracks and have the ability to convert chemical energy into mechanical work that powers cellular motility. Different types of motors are characterize ... [Phys. Rev. E 85, 021904 ] published .

Computed Tomography: Fundamentals, System Technology, Image Quality, Applications, 3rd revised and enlarged Edition.

Willi A. Kalender and William Hendee
Abstract not available. [Med. Phys. 39, 1152 (2012)] published Tue Feb 7, 2012.

Response to comment on QA procedures in radiation therapy are outdated and negatively impact the reduction of errors [Med. Phys. 38, 5835 (2011)]

Howard Ira Amols and Eric E. Klein
Abstract not available. [Med. Phys. 39, 1151 (2012)] published Tue Feb 7, 2012.

Comment on QA procedures in radiation therapy are outdated and negatively impact the reduction of errors [Med. Phys. 38, 5835 (2011)]

Fritz Hager
Abstract not available. [Med. Phys. 39, 1150 (2012)] published Tue Feb 7, 2012.

MR-guided adaptive focusing of therapeutic ultrasound beams in the human head

L. Marsac, D. Chauvet, B. Larrat, M. Pernot, B. Robert et al.

Determination of absorbed dose to water around a clinical HDR Ir source using LiF:Mg,Ti TLDs demonstrates an LET dependence of detector response

Asa Carlsson Tedgren, Rouba Elia, Hakan Hedtjarn, Sara Olsson, and Gudrun Alm Carlsson

Metal artifact reduction for CT: Development, implementation, and clinical comparison of a generic and a scanner-specific technique

Raoul M. S. Joemai, Paul W. de Bruin, Wouter J. H. Veldkamp, and Jacob Geleijns

Macroscopic model of self-propelled bacteria swarming with regular reversals

Richard Gejji, Pavel M. Lushnikov, and Mark Alber
Periodic reversals in the direction of motion in systems of self-propelled rod-shaped bacteria enable them to effectively resolve traffic jams formed during swarming and maximize the swarming rate of the colony. In this paper, a connection is established between a microscopic one-dimensional cell-ba ... [Phys. Rev. E 85, 021903 ] published .

Irradiation of the prostate and pelvic lymph nodes with an adaptive algorithm

A. B. Hwang, J. Chen, T. B. Nguyen, A. G. Gottschalk, M. R. Roach, III et al.

Can volumetric modulated arc therapy with flattening filter free beams play a role in stereotactic body radiotherapy for liver lesions? A volume-based analysis

Giacomo Reggiori, Pietro Mancosu, Simona Castiglioni, Filippo Alongi, Chiara Pellegrini et al.

Comparisons of treatment optimization directly incorporating systematic patient setup uncertainty with a margin-based approach

Joseph A. Moore, J. James. Gordon, Mitchell Anscher, Joaquin Silva, and Jeffrey V. Siebers

A pseudo-time EnKF incorporating shape based reconstruction for diffuse optical tomography

Tara Raveendran, Saurabh Gupta, Ram Mohan Vasu, and Debasish Roy

Schottky barrier control gate-type carbon nanotube field-effect transistor biosensors

Masuhiro Abe, Yasuhide Ohno, and Kazuhiko Matsumoto
We propose a unique structure for carbon nanotube field-effect transistors (CNT-FETs/with a Schottky barrier control gate (SBC gate) to improve the sensitivity of CNT-FET biosensors. The performance of the new biosensors was compared with conventional devices with back gate-type CNT-FETs both throug ... [J. Appl. Phys. 111, 034506 (2012)] published Mon Feb 6, 2012.

A Tandetron as proton injector for the eye tumor therapy in Berlin

J. Rohrich, T. Damerow, W. Hahn, U. Muller, U. Reinholz et al.
The therapy of eye tumors with fast protons is an excellent tool giving very high local control rates. At the Helmholtz-Zentrum Berlin (HZB) almost 1800 patients were treated since 1998. A 2 MV Tandetron was installed as injector for the k = 132 HZB cyclotron. Using the standard 358 duoplasmatron io ... [Rev. Sci. Instrum. 83, 02B903 (2012)] published Mon Feb 6, 2012.

Nucleobase adsorbed at graphene devices: Enhance bio-sensorics

Bo Song, Gianaurelio Cuniberti, Stefano Sanvito, and Haiping Fang
Graphene as a good material for sensing single small molecules is hardly believed to identify bio-molecules via electrical currents. This is because bio-molecules tend to bind to graphene through non-covalent bonds, such as pi-pi stacking interaction, which is not customarily considered to induce a ... [Appl. Phys. Lett. 100, 063101 (2012)] published Mon Feb 6, 2012.

Stochastic mapping of the Michaelis-Menten mechanism

Eva Doka and Gabor Lente
The Michaelis-Menten mechanism is an extremely important tool for understanding enzyme-catalyzed transformation of substrates into final products. In this work, a computationally viable, full stochastic description of the Michaelis-Menten kinetic scheme is introduced based on a stochastic equivalent ... [J. Chem. Phys. 136, 054111 (2012)] published Mon Feb 6, 2012.

Enhanced bubble formation in looped short double-stranded DNA

O-chul Lee and Wokyung Sung
Recent experiments have shown the double-stranded (ds) DNAs readily bend and loop over the scale much shorter than their persistence length (50 nm). In an effort to unveil this seemingly surprising phenomenon, we study the emergence of bubbles in short ds DNA loops by simulating the breathing DNA mo ... [Phys. Rev. E 85, 021902 ] published .